(Phoenix - July 30, 2025) – An international study is shedding new light on a concerning trend involving an alarming rise in gastrointestinal (GI) cancers in adults under the age of 50 prompting calls from experts with the Dignity Health Cancer Institute at St. Joseph’s for increased awareness and proactive screening measures.
The study found cases of gastrointestinal cancers, which include colorectal, esophageal and stomach cancers, spiked among younger adults between 2014-2025. The most dramatic early-onset increase was among colorectal cancer which had the largest, according to the data.
“This trend is concerning as GI cancers historically affected older patients,” said Dr. Ronald Gagliano, Chair of Surgery and Oncology with the Dignity Health Medical Group and practicing colorectal surgeon. “Early detection is more important than ever. It’s important for patients and providers to be aware and take potential symptoms seriously - especially if they persist over time.”
Some symptoms to be aware of include abdominal pain or cramping, unexplained weight loss, heart burn that doesn’t go away and changes in bowel habits.
Although the study did not reveal a certain reason behind the spike, the data did reveal clues that lifestyle factors, such as obesity, diet and smoking, may play a role along with environmental exposures and a person’s genetic risk.
“While patients can’t change their DNA, maintaining a balanced diet and getting regular exercises are small steps toward preventing some cancers,” said Dr. Gagliano. “Unfortunately, cancer isn’t always preventable and we are here to care for you when it matters most.”
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