Dignity Health Chandler Regional to Conduct Trauma Research Study

Community invited to provide feedback

(Chandler, Ariz. - Nov. 7, 2025) – Dignity Health Chandler Regional Medical Center is conducting a research study that will look at whether calcium, vasopressin, or both early in the course of treatment would help severely injured patients that lose a lot of blood survive their injuries.

The CAlcium and VAsopressin following Injury Early Resuscitation (CAVALIER) trial will include approximately 1,050 people aged 18 to 90. Patients who have traumatic injuries with loss of blood may be enrolled by participating emergency medical personnel during their transportation to the hospital or after arrival to Chandler Regional’s Level I Trauma Center. 

CAVALIER is an Exception from Informed Consent (EFIC) trial, meaning that the trial requires performing a potentially life-saving intervention in people who are too injured to give permission. This study will look at treatment for patients who have a traumatic injury and have lost a lot of blood. These patients are too injured to give permission before receiving the study drug. Permission for continued participation will be obtained from patients once they are able, or from their family members, as soon as possible.

For more information about CAVALIER or to complete an anonymous survey on your thoughts about this EFIC study, please visit:

• https://www.litesnetwork.org/cavalier/ (English) or

• https://www.litesnetwork.org/cavalier/spanish/  (Spanish).

The results of the study will be published in a peer-reviewed scientific journal and will be presented at suitable scientific meetings.  A brief summary of the study results written in lay person’s terms will be disseminated to the communities participating in the study through our websites and the clinicaltrials.gov website.

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